Lactic acidosis in patients with diabetes

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Lactic acidosis in patients with diabetes.

INTRODUCTION Lactic acidosis is a relatively rare complication diagnosed in patients with diabetes. OBJECTIVES The aim of this study was to identify causes of lactic acidosis in patients with diabetes and to measure the extent of metabolic disturbances based on the available laboratory test results. PATIENTS AND METHODS A total of 29 diabetic patients aged 20-87 years were admitted to the I...

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Epidemiology of lactic acidosis in type 2 diabetes patients with metformin in Japan

PURPOSE To estimate the incidence of lactic acidosis (LA) and role of metformin in Japanese patients with type 2 diabetes mellitus (T2DM) treated with anti-diabetes drugs. METHODS This retrospective propensity score matched cohort study was conducted using the Japanese Medical Data Vision claims database. T2DM patients aged 18 or above who received diabetes drugs during January 2010 through A...

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Berberine protects against metformin-associated lactic acidosis in induced diabetes mellitus

Objective(s): Causality of occurrence of metformin-associated lactic acidosis (MALA) is a clinical problem. Currently, there is no drug available to prevent MALA. The present study was conducted to evaluate the protective effect of Berberine (BBR) against MALA in induced diabetic rat model. Materials and Methods: A sample of 75 healthy male Wistar rats was randomly selected according to inclusi...

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Lactic Acidosis In Critically Ill Patients

Lactic acidosis is defined as increase in blood lactate levels in association with acidemia. It should be suspected in all patients presenting with shock & decreased mayocardial contractility. The patients with lactic acidosis have high mortality. However, the prognosis and case fatality are completely dependent on underlying disease in each patient with lactic acidosis being an independent ind...

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The phantom of lactic acidosis due to metformin in patients with diabetes.

M etformin is the only biguanide that is available in the U.S. Another biguanide, phenformin, had been used since the 1950s, but was declared an “imminent hazard” in 1976 because of lactic acidosis (1). At the time of its removal from the market, there had been 306 documented cases of phenformin-associated lactic acidosis (2), including 1 fatal and 2 nonfatal cases in the randomized controlled ...

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ژورنال

عنوان ژورنال: Polish Archives of Internal Medicine

سال: 2013

ISSN: 1897-9483

DOI: 10.20452/pamw.1619